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据John Bell[Nature,2011,477(7362):99-102]报道,加拿大渥太华医院研究所通过静脉注射释放病毒的方法可以造成肿瘤持续而广泛的感染而不会伤害人类正常组织。研究还首次证明,通过静脉注射病毒,肿瘤会选择性表达一种外部基因。研究选择23例(7例来自渥太华医院)已发生多个器官转移、常规治疗无效的晚期癌症患者。这些患者分别接受了5种剂量的病毒JX-594单次静脉注射,并在8～10 d后进行了活组织检查。在两个最高剂量组的87%患者中发现了病毒在肿瘤中复制的证
According to John Bell [Nature, 2011, 477 (7362): 99-102], the method of releasing the virus by intravenous injection at the Ottawa Hospital Institute in Canada can cause a sustained and widespread infection of the tumor without harming human normal tissues. The study also shows for the first time that by intravenous injection of a virus, the tumor selectively expresses an external gene. Study selected 23 patients (7 from the Ottawa Hospital) had multiple organ metastases, conventional treatment of advanced cancer patients. These patients received a single intravenous injection of 5 doses of the virus, JX-594, and biopsy 8 to 10 days later. Evidence of viral replication in tumors was found in 87% of the two highest dose groups