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目的考察不同剂量乌药醚内酯对大鼠肝损伤模型的保护作用。方法 60只健康SD大鼠,♂,随机分为空白对照组、模型对照组、乌药醚内酯低、中、高剂量组及联苯双酯组(阳性对照组),除空白对照组外,其余5组采用CCl4腹腔注射建立肝损伤大鼠模型,造模期间各组给予相应的药物或等体积的水,造模6周后处死大鼠取血清,测定血清ALT、AST、SOD、GSH-Px活性及MDA含量,取肝脏组织染色切片观察病理变化。结果与模型对照组对比,乌药醚内酯能剂量依赖性降低模型大鼠血清ALT、AST活性;高剂量组还能显著升高模型大鼠血清SOD、GSH-Px活性,降低MDA含量,显著降低肝脏组织的病理变化评分。结论乌药醚内酯可能通过提高抗氧化能力抑制CCl4诱导大鼠肝损伤。
Objective To investigate the protective effect of different doses of U.V.Elactone on rat liver injury model. Methods Sixty healthy SD rats were randomly divided into blank control group, model control group, low, medium and high dose of WUP and Bifendate group (positive control group), except for the blank control group , And the other 5 groups were given intraperitoneal injection of CCl4 to establish a rat model of liver injury. During the modeling period, corresponding drugs or equal volumes of water were given to each group. After 6 weeks of modeling, the rats were killed and the serum ALT, AST, SOD, GSH -Px activity and MDA content, take the liver tissue sections to observe the pathological changes. Results Compared with the model control group, VE could decrease the serum ALT and AST activity of model rats in a dose-dependent manner. The high dose group also significantly increased the activities of SOD and GSH-Px in serum and MDA content in model rats Reduce pathological changes in liver tissue score. Conclusion Wuliang et al lactone may inhibit CCl4-induced liver injury in rats by increasing the antioxidant capacity.