长链非编码RNA(long non-coding RANs，lncRNAs)是指长度超过200个核苷酸且无编码蛋白质功能的一类非编码RNA。近年来研究发现，lncRNAs广泛参与各种生物学过程，如调控细胞的分化、增殖、转移和凋亡等。lncRNAs的异常表达与人类各种疾病尤其与恶性肿瘤密切相关。其中反义lncRNAs是从编码或非编码基因的反义链转录生成的一类lncRNA。在哺乳动物细胞中，反义lncRNAs约占全部lncRNAs的20%，该类lncRNAs能通过调控其附近基因的转录影响细胞的生物学活动，参与包括胃癌在内的肿瘤的发生和发展，相关研究已成为当今肿瘤研究领域的热点。本文拟结合国内外最新研究报道，对近年来在胃癌研究中已经明确有差异变化的反义lncRNAs及其功能加以综述。“,”Long non-coding RNAs (lncRNAs) are a class of non-coding RNAs with a length of more than 200 nucleotides and have no function of coding protein.Recent studies found that lncRNAs are widely involved in various biological processes, such as regulating cell differentiation, proliferation, metastasis and apoptosis, etc., and that the abnormal expression of lncRNAs is closely related to various human diseases, especially malignant tumors.Among them, antisense lncRNAs are generated by reverse transcription of coding genes.In mammalian cells, antisense lncRNAs account for about 20% of all lncRNAs.This kind of lncRNAs can influence the biological activities of cells by regulating the transcription of nearby genes, and the occurrence and development of tumors including gastric cancer.Relevant studies have become a hot spot and an important scientific issue in the field of cancer research.This review intends to summarize the antisense lncRNAs and their functions that have been clearly differentiated in gastric cancer in recent years by combining the latest research reports at home and abroad.