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自由基氟烷基化是向有机分子中引入氟烷基的一类非常重要的方法,也是目前有机化学研究的热点之一.近几年来,由于广泛的官能团兼容性和温和的反应条件等优点,可见光促进的氧化还原催化反应得到了长足的发展,已经成为化学键的构建和活化的有力工具.因此,光氧化还原催化的自由基氟烷基化反应,作为向有机化合物中引入氟烷基的有效途径,受到了广泛关注.本文报道了我们发展的氟烷基砜作为一类方便易得的新型氟烷基自由基前体,在可见光氧化还原催化下实现对烯烃的自由基氟烷基化反应.该反应可以高效地向芳基烯烃中引入三氟甲基、二氟甲基、1,1-二氟乙基、苯基二氟甲基等各种含氟烷基基团,并实现对芳基烯烃的双官能团化转化.
Free radical fluoroalkylation is a very important method to introduce fluoroalkyl groups into organic molecules and is one of the hot topics in organic chemistry.In recent years, due to its extensive functional group compatibility and mild reaction conditions , The visible-light-promoted redox catalytic reaction has made considerable progress and has become a powerful tool for the formation and activation of chemical bonds. Therefore, the photo-oxidation reduction catalyzed free-radical fluoroalkylation reaction, as a method of introducing a fluoroalkyl group into an organic compound Effective approach has received widespread attention.In this paper, we report the development of fluoroalkylsulfones as a new class of easily accessible new fluoroalkyl radical precursors, in the visible light redox catalysis of olefin free radical fluoroalkylation The reaction can efficiently introduce various fluoroalkyl groups such as trifluoromethyl, difluoromethyl, 1,1-difluoroethyl and phenyldifluoromethyl into aryl olefins and realize Bifunctional conversion of aryl olefins.