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2例明确诊断AMI患者在行急诊冠脉支架植入术后发生急性血栓形成,即给予国产血小板Ⅱb/Ⅲa受体拮抗剂盐酸替罗非班(欣维宁)治疗,先以10μg/kg的剂量在3 min内静注,随后以0.15μg/kg.min-1的剂量维持静滴36 h。结果急性血栓在5 min内完全消失,同时观察1周未见明显的不良反应。盐酸替罗非班的应用,为抑制支架急性血栓的形成开辟了一条有效的途径
Two patients with definite diagnosis of acute myocardial infarction (AMI) developed acute thrombosis after emergency coronary stent implantation. That is, they were treated with tirofiban hydrochloride (Ⅱ), a platelet receptor antagonist of platelet Ⅱ b / Ⅲa, at 10 μg / kg The dose was intravenously administered within 3 min followed by an intravenous infusion of 0.15 μg / kg.min-1 for 36 h. Results Acute thrombus completely disappeared in 5 min, while no significant adverse reactions observed for 1 week. The application of tirofiban hydrochloride has opened up an effective way to inhibit the formation of acute thrombosis