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目的：评价前列地尔联合缬沙坦治疗糖尿病肾病的效果。方法回顾分析我院收治的88例糖尿病肾病患者，均分为两组，对照组41例仅接受前列地尔用药治疗，观察组47例接受前列地尔联合缬沙坦用药治疗，比较两组患者的治疗效果以及治疗前后的尿蛋白水平。结果研究表明，治疗后观察组患者的治疗有效率、24h尿蛋白定量与对照组相比有明显差异，有统计学意义（P＜0.05）。结论糖尿病肾病患者采用前列地尔联合缬沙坦用药治疗，有效降低蛋白尿，显著改善患者生活质量。“,”Objective: To evaluate the alprostadil combined effects of valsartan treatment of diabetic nephropathy. Methods: A total of 88 cases of diabetic nephropathy patients were divided into two groups, a control group of 41 patients received only drug alprostadil treatment, observation group, 47 cases accepted alprostadil valsartan drug treatment, comparing two treatment of patients, and urinary protein levels before and after treatment. Results: The study showed that the treatment groups were observed treatment efficiency, there are significant differences compared to the 24h urinary protein and the control group was statisticaly significant (P <0.05). Conclusion: The patients with diabetic nephropathy using alprostadil valsartan drug therapy, can significantly improve the quality of life of patients, the effect is significant.