目的:探讨重度子痫前期合并胸腹腔积液患者的相关因素及其妊娠结局,以提供临床诊疗依据。方法:32例重度子痫前期合并胸腹腔积液患者作为观察组,31例未合并胸腹腔积液患者作为对照组,对比两组患者年龄、产次、是否多胎、不良孕产史、血压、血浆白蛋白以及24 h尿蛋白定量以探讨重度子痫前期合并胸腹腔积液的相关因素,同时对比两组患者妊娠结局。结果:两组患者在是否多胎、血压、血浆白蛋白、24 h尿蛋白定量等方面比较差异有统计学意义(P<0.05或P<0.01),且双胎、血压较高、血浆白蛋白较低、24 h尿蛋白定量较高的重度子痫前期患者出现胸腹腔积液几率较高。观察组产妇心衰、死亡以及胎儿早产、新生儿窒息、围生儿死亡发生率均显著高于对照组,差异有统计学意义(P<0.05或P<0.01)。结论:重度子痫前期合并胸腹腔积液可明显增加围产期母婴死亡率及其他严重并发症发生率,对于合并多胎、孕妇血压水平高、低蛋白血症以及蛋白尿等因素的孕产妇应及早给予合理治疗,以保证围产期母婴安全。 Objective: To investigate the related factors and their pregnancy outcome in patients with severe preeclampsia complicated with ascites and pleural effusion to provide the basis for clinical diagnosis and treatment. Methods: Thirty-two patients with severe preeclampsia with pleural effusion and ascitic fluid were selected as the observation group and 31 patients without pleural effusion as control group. The patients’ age, parity, whether multiple births, poor pregnancy history, blood pressure, Plasma albumin and 24 h urinary protein to explore the related factors of severe preeclampsia combined with pleural effusion, as well as comparing the pregnancy outcome of the two groups. Results: There was significant difference between the two groups in terms of multiple births, blood pressure, serum albumin, 24 h urinary protein (P <0.05 or P <0.01), twins, high blood pressure and plasma albumin Low, 24 h urinary protein high in patients with severe preeclampsia have a higher probability of pleural effusion. The observation group maternal heart failure, death and fetal premature birth, neonatal asphyxia, perinatal mortality were significantly higher than the control group, the difference was statistically significant (P <0.05 or P <0.01). Conclusion: Severe preeclampsia combined with pleural effusion can significantly increase perinatal maternal and infant mortality and other serious complications, combined with multiple births, high blood pressure in pregnant women, hypoproteinemia and proteinuria and other factors of pregnant women Should be given reasonable treatment as soon as possible to ensure the safety of perinatal mother and child.