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采用ConA诱导的实验性小鼠肝损伤模型观察国产大剂量胸腺肽对小鼠肝脏的保护作用及对肝细胞凋亡的影响.结果表明:肝损害组与正常组ALT和TNF-α测定值有显著性差异,光镜检查肝损害组亦有严重的肝损伤;用大剂量胸腺肽腹腔注射一周后可明显减弱ConA对肝组织的损伤;对小鼠肝组织Fas抗原阳性细胞情况研究表明,肝损害组Fas抗原阳性细胞较为普遍,正常组无阳性细胞,胸腺肽组阳性细胞明显减弱.本实验结果提示大剂量胸腺肽对ConA诱导的肝损伤有保护作用;ConA可诱导肝细胞凋亡,大剂量胸腺肽对凋亡有抑制作用.
To observe the protective effects of domestic high-dose thymosin on the liver of mice induced by ConA and the effect on hepatic cell apoptosis in experimental model of liver injury induced by ConA.The results showed that the values of ALT and TNF-α in liver damage group and normal group were significantly There was also significant liver damage by light microscopy in liver damage group. One week after intraperitoneal injection of high-dose thymosin, the damage of ConA to liver tissue was significantly reduced. The study of Fas antigen-positive cells in liver showed that liver damage group Fas antigen positive cells are more common in normal group without positive cells, thymosin group positive cells decreased significantly.The results suggest that high doses of thymosin on ConA-induced liver injury protective effect; ConA can induce hepatocyte apoptosis, high-dose thymosin on the apoptosis Death has inhibitory effect.