To investigate the effect of cholecystokinin octapeptide (CCK-8) on oxygen-induced convulsions in rats.

One hundred male SD rats were randomly divided into nine groups before stainless steel cannula was placed into lateral ventricle, striatum and hippocampus. The animals were allowed to recover from surgery for 5～7d before microinjection of CCK-8 or equal volume of normal saline via the cannula. Then the animals in each group were exposed, one at a time, to 700 kPa (ATA) hyperbaric oxygen to observe the initial time of convulsions (ITC), severity of convulsions (SOC) and survival time(ST) of them.

Injection of CCK-8 into lateral ventricle or striatum or hippocampus could obviously delay ITC, alleviate SOC and prolong ST. There were no marked differences between injection of CCK-8 into lateral ventricle or striatum or hippocampus for the prevention of oxygen-induced convulsions in rats.

Injection of CCK-8 into lateral ventricle or striatum or hippocampus could play some preventive role for the oxygen-induced convulsions in rats and there were no obvious differences between different injection sites, which suggested that the changes of CCK-8 contents in the, brain of rats were correlative with oxygen-induced convulsions.