本文测定了小鼠肝癌腹水瘤细胞Hca-F25/CL-A_2经二甲亚砜(DMSO)诱导分化前后钙恒稳的有关指标。结果表明,细胞经DMSO诱导向正常形态转化,细胞内总钙水平、胞液Ca~(2+)浓度和微粒体Ca~(2+)-ATP酶活性均明显下降,线粒体内钙含量显著提高。结果提示,细胞内钙恒稳状态与肿瘤细胞的分化和增殖密切相关。 This article measured the mouse liver cancer ascites tumor cells Hca-F25/CL-A2 dimethyl sulfoxide (DMSO) induced differentiation of calcium stability indicators before and after. The results showed that the cells were induced to normal morphology by DMSO, and the total calcium level, cytosolic Ca~(2+) concentration and microsomal Ca~(2+)-ATPase activity were significantly decreased, and the mitochondrial calcium content was significantly increased. . The results suggest that the intracellular calcium steady state is closely related to the differentiation and proliferation of tumor cells.