【摘 要】
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The relationship between the tenth exon C825T of G-protein β3 subunit(GNB3)genetic polymorphism and hypertension in the Uygur population of China was investiga
【机 构】
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Department of Biology,School of Environment and Chemical Engineering,Luoyang University,Luoyang 4710
论文部分内容阅读
The relationship between the tenth exon C825T of G-protein β3 subunit(GNB3)genetic polymorphism and hypertension in the Uygur population of China was investigated.A nested case-control studv (n=73 8)was carried out.Polymerase chain reaction-restriction fragment length polymorphism(PeR-RFLP)technique was used to genotype GNB3 C825T polymorphism in 354 hypertensive(HT) and 384 normotensive (NT)Uygur subjects.The distributions of GNB3 C825T genotypes were CC(27.2%),TT(42.9%),and CT(29.9%)in the hypertensive subjects and CC(27.7%),TT (42.4%),CT(29.9%)in the normotensive subjects.There were no significant difierences in the genotype distributions between the two groups(X2=0.0262 P=0.99).The T allele was 51.4%in hvpertensive subjects and 51.2%in normotensive subjects,which,between the two groups,was not a significant difierence(X2=0.0016 P=0.97).Further analysis shows that there is no association between C825T genotypes and age,body mass index(BMI),Glucose(GLU),Triglyceride(TG),Cholesterol(CHO),systolic blood pressure(SBP)and diastolic blood pressure(DBP).No evidence was found to suggest an association between GNB,C825T polymorphism and hypertension in the Uygur population of China.
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