目的　通过分析脑出血与酪神经肽变化的相关性及进食对 NPY含量的影响 ,为颅脑损伤后进食时机的选择提供理论指导。方法　利用脑出血动物模型动态观察脑出血不同时期及空腹与进食后血浆、胃液中酪神经肽含量的变化。结果　在急性脑损伤初期 ,血浆及胃液中 NPY浓度增高 ,餐后 NPY降低。结论　进餐可能缓解动物对脑损伤的应激反应 ,动态测定血浆及胃液中NPY含量 ,有助于对急性颅脑损伤选择进食时机提供指导 Objective To analyze the relationship between cerebral hemorrhage and neuropeptide changes and the effect of feeding on the content of NPY, so as to provide theoretical guidance for choosing the timing of feeding after craniocerebral injury. Methods The animal model of intracerebral hemorrhage was used to dynamically observe the changes of the contents of neuropeptides in plasma and gastric juice at different stages of cerebral hemorrhage and after fasting and ingestion. Results In the early stage of acute brain injury, the concentration of NPY in plasma and gastric juice increased and the postprandial NPY decreased. Conclusions Meal intake may relieve the stress response of animals to brain injury and dynamically determine the content of NPY in plasma and gastric juice, which may be helpful to choose the timing of feeding in acute craniocerebral injury