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目的分析冠心病心绞痛患者血清TNF-α、BNP和IL-18水平的相关性。方法选取冠心病心绞痛患者102例作为观察组,另选取体检中心健康者102例作为对照组,采用酶联免疫夹心法(ELISA)分别检测肿瘤坏死因子-α(TNF-α)、脑利钠肽(BNP)和白细胞介素-18(IL-18)水平。结果观察组血清TNF-α、BNP和IL-18水平均显著高于对照组,差异均有统计学意义(P<0.05或P<0.01);TNF-α水平分别与BNP和IL-18呈正相关(r=0.689,r=0.728,P均<0.05),BNP水平与IL-18水平亦呈明显正相关(r=0.835,P<0.05)。结论临床上可将联合检测TNF-α、BNP和IL-18三项水平作为冠心病心绞痛的辅助诊断指标。
Objective To analyze the correlation between serum TNF-α, BNP and IL-18 levels in patients with coronary heart disease and angina pectoris. Methods 102 patients with angina pectoris were selected as observation group and 102 healthy subjects were selected as control group. The levels of tumor necrosis factor-α (TNF-α) and brain natriuretic peptide (BNP) and interleukin-18 (IL-18) levels. Results The levels of serum TNF-α, BNP and IL-18 in the observation group were significantly higher than those in the control group (P <0.05 or P <0.01). The levels of TNF-α were positively correlated with BNP and IL-18 (r = 0.689, r = 0.728, P <0.05). There was also a positive correlation between BNP level and IL-18 level (r = 0.835, P <0.05). Conclusions The combined detection of TNF-α, BNP and IL-18 levels can be clinically used as an auxiliary diagnostic indicator of angina pectoris.