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因皮质脊髓束(corticospinal tract,CST)损伤而造成的运动功能丧失可得到一定恢复,但关于大脑运动区占位性病变对健侧CST结构功能影响的研究却相对较少。该研究采用两只健康猕猴行球囊置入术建立大脑运动区占位性病变模型,行4次磁共振弥散张量成像(diffusion tensor imaging,DTI)扫描,检测手术区对侧CST的FA值(“各向异性”值),发现球囊置入术后当天,对侧CST的FA值无明显变化,但随时间的延长升高,球囊取出术后一周更为明显。实验表明该模型可行、可靠,从DTI观察到病变健侧CST出现代偿,即使占位解除短期内这一作用仍明显,提示健侧CST共同参与瘫痪肢体功能的恢复。
Loss of motor function due to corticospinal tract (CST) injury can be restored to some extent, but there are relatively few studies on the effects of space-occupying lesions on the structure of contralateral CST. In this study, two healthy macaque balloon-operated patients were enrolled in this study to establish a space-occupying lesion model of brain motion. Four consecutive magnetic resonance diffusion tensor imaging (DTI) scans were performed to detect FA values of contralateral CST ( “Anisotropy ” value). It was found that on the day after balloon implantation, there was no significant change in the FA value of the contralateral CST. However, the FA value of the contralateral CST increased more significantly with the extension of time. Experiments show that the model is feasible and reliable. From the DTI observation, the contralateral CST of the lesion is compensated. This effect is obvious even in the short term, suggesting that the contralateral CST can participate in the recovery of paralyzed limbs.