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目的:探索五劳七损方治疗强直性脊柱炎(AS)的有效性、安全性及可能的作用机理。方法:本研究应用ELISA的实验方法检测45例AS患者(AS组)治疗前后及50名健康人(健康组)血清Dickkopf-1(DKK-1)蛋白水平,并检测AS组治疗前后血沉(ESR)、C反应蛋白(CRP)含量及相关临床疗效评价指标。治疗过程中观察不良反应。结果:治疗前AS组血清DKK-1水平明显低于健康组(P<0.05),经五劳七损方治疗后血清DKK-1水平较治疗前明显升高(P<0.05),且与对照组比较差异无统计学意义(P<0.05)。治疗后ESR和CRP较治疗前均明显降低(P<0.05或P<0.01);相关临床疗效评价指标均较治疗前均明显改善(P<0.05)。患者治疗过程中未见明显不良反应。结论:五劳七损方改善AS患者临床症状、体征疗效显著,其作用机制可能是通过升高血清DKK-1水平实现的。
Objective: To explore the effectiveness, safety and possible mechanism of treatment of ankylosing spondylitis (AS) by Wulao-Qiu-Fang. Methods: The serum levels of Dickkopf-1 (DKK-1) in 45 AS patients before and after treatment and in 50 healthy people (healthy group) were detected by ELISA. The serum levels of ESR ), C-reactive protein (CRP) levels and related clinical efficacy evaluation index. Adverse reactions observed during treatment. Results: Before treatment, serum DKK-1 level in AS group was significantly lower than that in healthy group (P <0.05). Serum DKK-1 level was significantly higher in treatment group than that in control group (P <0.05) There was no significant difference between the two groups (P <0.05). After treatment, the ESR and CRP were significantly lower than those before treatment (P <0.05 or P <0.01). The clinical evaluation indexes were significantly improved (P <0.05). No significant adverse reactions were observed during the course of treatment. Conclusion: The Wulongsanjisang decoction can improve the clinical symptoms and signs of AS patients. Its mechanism may be through elevating serum DKK-1 level.