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本研究回顾性总结中山大学附属第一医院神经科诊治的3例增龄相关性脑小血管病和特发性正常颅压脑积水共病案例，发现患者均表现为步态、认知及小便控制障碍。颅脑影像学提示脑小血管病及交通性脑积水。脑脊液Aβ42下降。APOE基因分型分别为ε3/ε4，ε3/ε3，ε2/ε3。给予全因个体化治疗后3例患者症状稳定或好转。“,”Three cases with age-related cerebral small vessel disease and normal pressure hydrocephalus in the Department of Neurology of Sun Yat-sen University were retrospectively reviewed. All the patients exhibited gait disturbance, cognitive impairment and urinary incontinence. Meanwhile, the Craniocerebral imaging demonstrated cerebral small vessel disease and communicating hydrocephalus. The cerebralspinal fluid (CSF) Aβ42 levels decreased, and apolipoprotein E (APOE) genotypes were ε3/ε4,ε3/ε3,ε2/ε3, respectively. After treatment in an all-cause individualized manner, the symptoms of 3 patients were stable or improved.