既往研究认为柴胡桂枝汤有预防胰腺炎的效果,为了阐明其作用机制,本次将1％柴胡桂枝汤提取剂混入饲料,长期(4周)投予Wistar系雄性大鼠(体重300～350g);对照组投予不含柴胡桂枝汤的相同饲料,以胶原酶消化法得游离胰腺腺泡,通过perifusion法,体外实验探讨了胆囊收缩素(CCK)刺激时的淀粉酶分泌反应,并进行病理形态学检查。 Previous studies have suggested that Chaihu Guizhi Decoction has the effect of preventing pancreatitis. In order to elucidate its mechanism of action, 1% Chaihu Guizhi Decoction is mixed into the feed, and long-term (4 weeks) is administered to Wistar male rats (body weight 300-350g). The control group was administered with the same diet without Chaihu Guizhi Decoction, and free pancreatic acini was obtained by collagenase digestion. The amylase secretion response stimulated by cholecystokinin (CCK) was investigated by in vitro experiments and pathological examination was performed. Morphological examination.