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目的:观察速降糖对链脲佐菌素(STZ)糖尿病大鼠血糖及心重指数、心肌组织血管紧张素Ⅱ受体1(AT1)表达的影响,探讨速降糖对糖尿病(DM)大鼠病变早期心肌保护作用的机制。方法:通过腹腔注射STZ建立DM大鼠模型,正常组、模型组给生理盐水,大小剂量组给225%、75%速降糖合剂,西药Ⅰ组给二甲双胍(1.5%),西药Ⅱ组给二甲双胍(1.5%)与氯沙坦(0.05%)混悬液灌胃,每日1次,连续8周。结果:与正常组比较,模型组体重降低(P<0.01)、血糖升高(P<0.01)、心重指数增加(P<0.01)、AT1的表达显著增加。治疗组体重高于模型组、血糖低于模型组(P<0.05或P<0.01)、心重指数下降(P<0.01)、AT1表达降低,以大剂量组和西药Ⅱ组最为显著。结论:速降糖对DM大鼠病变早期心肌有良好保护作用,并且与剂量呈正相关。
OBJECTIVE: To observe the effect of fast hypoglycemia on blood glucose, heart index and expression of angiotensin II receptor 1 (AT1) in myocardial tissue of streptozotocin (STZ) diabetic rats, and to investigate the effects of hypoglycemia on diabetes (DM) rats. Mechanism of early myocardial protective effects of lesions. Methods: The DM rat model was established by intraperitoneal injection of STZ. The normal group and model group were given normal saline. The large and small dose group was given 225% and 75% fast hypoglycemic agent, the western medicine group I was given metformin (1.5%), and the western medicine group II was given metformin. (1.5%) gavage with losartan (0.05%) suspension once daily for 8 weeks. RESULTS: Compared with the normal group, the model group had decreased body weight (P<0.01), elevated blood glucose (P<0.01), increased heart index (P<0.01), and increased AT1 expression. The weight of the treatment group was higher than that of the model group, the blood glucose was lower than that of the model group (P<0.05 or P<0.01), the heart index was decreased (P<0.01), and the AT1 expression was decreased. The high-dose group and the western medicine II group were the most significant. Conclusion: The rapid hypoglycemia has a good protective effect on the early myocardium in the lesions of DM rats and is positively related to the dose.