目的探讨小剂量甲泼尼龙联合注射用单磷酸阿糖腺苷治疗小儿重度手足口病的临床疗效。方法选取2010年4月—2013年4月吉安县人民医院收治的重度手足口病患儿120例,随机分为观察组与对照组,各60例。对照组患儿予以注射用单磷酸阿糖腺苷治疗,观察组患儿在对照组基础上加用小剂量甲泼尼龙治疗。观察两组患儿临床疗效、住院时间、临床症状(发热、皮肤疱疹、四肢抖动、睡眠易惊)及不良反应发生情况。结果观察组患儿总有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿住院时间短于对照组,差异有统计学意义(P<0.05);观察组患儿发热、四肢抖动发生率低于对照组,差异有统计学意义(P<0.05);两组患儿皮肤疱疹、睡眠易惊发生率比较,差异无统计学意义(P>0.05);两组患儿均未发生严重不良反应。结论小剂量甲泼尼龙联合注射用单磷酸阿糖腺苷治疗小儿重度手足口病的临床疗效显著,可缩短患儿住院时间,改善患儿临床症状,且不良反应少。 Objective To investigate the clinical efficacy of small dose methylprednisolone injection combined with adenosine monophosphate for the treatment of severe hand-foot-mouth disease in children. Methods From April 2010 to April 2013, 120 children with severe hand-foot-mouth disease admitted to Ji’an People’s Hospital were randomly divided into observation group and control group, with 60 cases in each group. Children in the control group were treated with adenosine monophosphate. The children in the observation group were treated with methylprednisolone in small doses on the basis of the control group. The clinical efficacy, hospital stay, clinical symptoms (fever, skin herpes, limbs jitters, easy to sleep) and adverse reactions were observed in two groups of children. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). The hospitalization time of the observation group was shorter than that of the control group (P <0.05) Fever, limb jitter was lower than the control group, the difference was statistically significant (P <0.05); two groups of children with herpes zoster, sleep easy to shock the incidence of comparison, the difference was not statistically significant (P> 0.05) No serious adverse reactions occurred in children. Conclusions The small dose of methylprednisolone injection combined with adenosine monophosphate for the treatment of severe hand-foot-mouth disease in children has significant curative effect, which can shorten the hospitalization time and improve the clinical symptoms in children with less adverse reactions.