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目的:探讨钙、镁、铁、锌、铜、磷等微量元素变化与不良妊娠结局的相关性,为合理指导妊娠期检查、补充微量元素提供参考,以及为预防不良妊娠结局提供依据。方法:选择本院2012年6月-2013年9月体检的200例健康体检孕妇作为正常妊娠组,选择同期收治的200例发生不良妊娠结局的孕妇作为不良妊娠组。采用原子吸收分光光度法对两组孕妇血液中的钙、镁、铁、锌、铜、磷等微量元素的含量进行分析,对比两组孕妇血液中的钙、镁、铁、锌、铜、磷的含量。结果:不良妊娠组孕妇随着妊娠周期的增加,血液中的钙、铁、锌、磷含量不断降低,和同期正常妊娠组相比(P<0.05)。孕早期的不良妊娠组孕妇血液中的铜含量低于同期正常妊娠组(P<0.05);孕中期和孕晚期两组孕妇血液中的铜含量比较,差异无统计学意义(P>0.05)。镁、磷在两组孕妇血液中含量比较,差异无统计学意义(P>0.05)。结论:微量元素的变化可影响妊娠结局,微量元素钙、铁、锌、铜含量异常可能导致妊娠期间先兆流产、死胎及胎膜早破等不良妊娠结局的发生。孕妇应注意摄入足量的钙、镁、铁、锌、铜、磷等微量元素,对预防流产、死胎及胎膜早破的发生具有一定的积极意义。根据孕妇体内微量元素含量的变化,合理指导孕妇补充不同的微量元素饮食,有利于妊娠结局。
OBJECTIVE: To investigate the correlation between trace elements such as calcium, magnesium, iron, zinc, copper, phosphorus and unfavorable pregnancy outcomes in order to provide guidance for the proper guidance of pregnancy testing and trace elements supplementation and to provide evidences for the prevention of adverse pregnancy outcomes. Methods: Two hundred and seventy healthy pregnant women undergoing physical exam from June 2012 to September 2013 in our hospital were selected as the normal pregnancy group. Two hundred and seventy pregnant women with adverse pregnancy outcomes were selected as the adverse pregnancy group. The levels of trace elements such as calcium, magnesium, iron, zinc, copper and phosphorus in blood of two groups of pregnant women were analyzed by atomic absorption spectrophotometry. The levels of calcium, magnesium, iron, zinc, copper and phosphorus Content. Results: The levels of calcium, iron, zinc and phosphorus in the blood of pregnant women with adverse pregnancy continued to decrease with the increase of pregnancy cycle, compared with the normal pregnancy group (P <0.05). The content of copper in the blood of pregnant women in the first trimester was lower than that of the normal pregnancy in the second trimester (P <0.05). There was no significant difference in the copper content between the pregnant women and the third trimester pregnant women (P> 0.05). Magnesium and phosphorus levels in the two groups of pregnant women, the difference was not statistically significant (P> 0.05). CONCLUSION: The changes of trace elements may affect the outcome of pregnancy. Abnormal levels of trace elements calcium, iron, zinc and copper may lead to adverse pregnancy outcomes such as threatened abortion, stillbirth and premature rupture of membranes during pregnancy. Pregnant women should pay attention to adequate intake of calcium, magnesium, iron, zinc, copper, phosphorus and other trace elements, to prevent miscarriage, stillbirth and premature rupture of membranes has a certain positive significance. According to changes in pregnant women, the content of trace elements, reasonable guidance of pregnant women to supplement different trace elements diet, is conducive to pregnancy outcomes.