婴幼儿血管瘤是胚胎期血管形成过程中出现的一种先天性发育不良,发病率占新生儿良性肿瘤的10%[1],部分血管瘤由于生长部位的特殊性,可能危及生命,如婴幼儿声门下血管瘤(subglottic hemangioma,SGH),具有血管畸形和肿瘤的双重特征,占先天性喉部畸形的1.5%。50%的SGH患儿可同时伴有皮肤血管瘤[2]。婴幼儿SGH可能病因有:①雌激素水平增高,瘤体中有增高的特异性雌激素受体;②肥大细胞学说,肥大细胞直接刺 Infantile hemangiomas are congenital dysplasia that occurs during the process of embryonic vascularization and account for 10% of neo-natal benign tumors [1]. Some hemangiomas may be life-threatening due to the particularities of their growth sites. Subglottic hemangioma (SGH) has the dual features of vascular malformations and tumors, accounting for 1.5% of the congenital laryngeal deformities. 50% of children with SGH may be accompanied by cutaneous hemangiomas [2]. Possible causes of infant SGH are: ① increased estrogen levels, increased tumor specific estrogen receptor; ② mast cell theory, mast cells direct thorn