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目的 :观察健脾消痞浸膏对脾虚动物胃功能的影响。方法 :用大黄水煎剂造脾虚动物模型 ,以比色法测定液体的胃排空 ,胃残留物重量测定固体的胃排空 ,放射免疫法测定血浆胃动素 (MTL) ,用滴定法了解胃分泌功能。结果 :健脾消痞浸膏组胃内液体残留率显著降低 (P <0 .0 1) ;中、高剂量组胃内固体残留率降低 (P <0 .0 5 ,<0 .0 1) ;中、高剂量组血浆MTL、总酸度、总酸排出量升高 (P <0 .0 5 ,<0 .0 1) ;高剂量组胃液量显著升高 (P <0 .0 1)。结论 :健脾消痞浸膏促进脾虚动物胃排空液体及固体 ,提高血浆MTL ,促进胃液分泌。
Objective: To observe the effect of Jianpixiaopi extract on gastric function of spleen deficiency animal. METHODS: The spleen deficiency animal model was made with rhubarb water decoction. The gastric emptying of the liquid was determined by colorimetry. The gastric emptying of solid was determined by the weight of stomach residue. The plasma motilin (MTL) was determined by radioimmunoassay. Gastric secretion function. RESULTS: The residual rate of gastric fluid in the Jianpi Xiaoyu extract group was significantly decreased (P < 0.01); the residual rate of gastric solids was decreased in the middle and high dose groups (P <0. 05, <0. 01). Plasma MTL, total acidity and total acid output were increased in the medium and high dose groups (P < 0.05, <0.01); gastric juice volume was significantly increased in the high dose group (P <0.01). Conclusion: Jianpi Xiaoyu extract can promote the gastric emptying of liquid and solid in spleen-deficient animals, increase plasma MTL, and promote secretion of gastric juice.