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目的观察常规溶栓联合氯吡格雷治疗对急性ST段抬高型心肌梗死近期心脏事件的影响。方法符合入选条件的患者随机分为常规溶栓治疗组(34例)和氯吡格雷组(36例,在常规溶栓治疗的基础上即刻300mg,随后每日1次75mg,连用7d)。结果7d后氯吡格雷组复合终点(13.90%)与常规治疗组(29.41%)比较差异有统计学意义(P<0.05),而主要的副作用两组之间比较差异无统计学意义(P>0.05)。结论氯吡格雷对急性ST段抬高型心肌梗死患者的近期(7d)心脏事件是安全有效的。
Objective To observe the effect of conventional thrombolytic therapy combined with clopidogrel on recent cardiac events in patients with acute ST-segment elevation myocardial infarction. Methods Patients eligible for admission were randomized to receive conventional thrombolytic therapy (n = 34) and clopidogrel (n = 36). Immediately after thrombolytic therapy, 300 mg was given, followed by 75 mg once daily for 7 days. Results After 7 days, the composite end point of clopidogrel group (13.90%) was significantly different from that of conventional treatment group (29.41%) (P <0.05), while the main side effects were no significant difference between the two groups (P> 0.05). Conclusion Clopidogrel is safe and effective for the recent (7d) cardiac events in patients with acute ST-segment elevation myocardial infarction.