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目的：观察Ｃｏａｔｓ病的临床及病理改变。方法：复习本院眼科病理室１９５９～１９９４年经病理学证实的１９例Ｃｏａｔｓ病患者的临床资料和病理切片。结果：男１４例，女５例，年龄为１～１８岁，１０岁前发病者男性明显多于女性，随年龄增长，性别差异逐渐减少。病理改变主要是视网膜外层血管扩张充血，血管壁厚薄不均及结缔组织增生，晚期病例眼底多见视网膜脱离隆起，表面有血管改变和出血，视网膜下液中有泡沫细胞和胆固醇结晶，有的病例视网膜外层有钙化及骨化。结论：Ｃｏａｔｓ病是视网膜血管病变引起的视网膜多种病理变化，视网膜下液细胞学检查可作为本病与视网膜母细胞瘤鉴别诊断的可靠方法。
Objective: To observe the clinical and pathological changes of Coats disease. Methods: The clinical data and pathological sections of 19 patients with Coats disease confirmed by pathology in our hospital from 1959 to 1994 were reviewed. Results: There were 14 males and 5 females, aged from 1 to 18 years old. The incidence of males was significantly higher than that of females before the age of 10 years. With the increase of age, the gender differences decreased gradually. Pathological changes are mainly outer retinal dilatation and congestion, vascular wall thickness and uneven connective tissue hyperplasia, advanced cases of fundus retinal detachment more prominent surface vascular changes and bleeding, subretinal fluid foam cells and cholesterol crystals, and some Cases of retinal outer calcification and ossification. Conclusion: Coats’ disease is a variety of retinal pathological changes caused by retinal vascular lesions. Subretinal cytology can be used as a reliable method to differentiate this disease from retinoblastoma.