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由外伤、肿瘤切除、先天性畸形和严重牙周病导致的颌骨缺损,是目前口腔及颅颌面修复治疗面临的一大难题.携带特定生物信息的部分外泌体具有促进组织再生的作用,相比于干细胞移植,外泌体的免疫原性更低,便于储存和定量使用.本文综述外泌体在骨髓间充质干细胞、成骨细胞、破骨细胞和免疫细胞间相互转运的特点以及在颌骨相关疾病中的研究进展.“,”Large area defect of jaw caused by trauma,tumor resection,congenital malformation and periodontitis is a critial situation for oral and craniofacial reconstruction.Recent studies have shown that some exosomes carrying specific biological information play a role in promoting tissue regeneration.Compared to allogeneic stem-cell transplantation,exosomes have lower immunogenicity,and can facilitate storage and quantitative use,thus have great potential in tissue engineering.This article reviewed the regeneration process of jaw bone and the regulatory effect of exosomes transport on bone regeneration,as well as the research progress of exosomes in jaw bone-related diseases.