目的 观察临床护理路径在单孔胸腔镜肺叶切除术围手术期护理中的应用疗效。方法 我院2018年5月至2019年5月收治的60例单孔胸腔镜肺叶切除术患者为本次研究对象，按照围手术期是否行临床护理路径将所有患者分为对照组（30例：未行临床护理路径）与试验组（30例：行临床护理路径），比较两组患者护理干预效果。结果 试验组患者持续胸腔引流时间、术后首次下床活动时间、平均住院时间等相关资料以及术后3d各项免疫因子参数数值均优于对照组（P＜0.05）。试验组患者术后并发症发生率（10.00%）明显低于对照组（33.33“,”Objective To observe the effect of clinical nursing pathway in perioperative nursing of single-hole thoracoscopic pulmonary lobectomy.Methods Sixty patients who underwent single-port thoracoscopic lobectomy in our hospital from May 2018 to May 2019 were included in this study. All patients were divided into control group (30 cases: patients without clinical nursing pathway) and experimental group (30 cases: patients with clinical nursing pathway) according to whether or not clinical nursing pathway was applied during erioperative period. Nursing intervention effects of the two groups were compared. Results The duration of continuous thoracic drainage， the first time out of bed after operation， the average ength of hospitalization and the parameters of immune factors in the experimental group were better than those in the control group (P＜0.05). The incidence of postoperative complications in the experimental group was significantly lower (10.00%) than that in the control group (33.33%) (P＜0.05). Conclusion The effect of perioperative clinical nursing pathway intervention for patients undergoing single-hole thoracoscopic lobectomy is better than that of routine nursing.