甲砜霉素是第二代氯霉素类广谱抗菌药物,对革兰氏阳性菌和革兰氏阴性菌都具有很好的抑制作用,在水产养殖中对鱼和甲鱼等水生动物的疾病防治有非常显著的疗效。随着对甲砜霉素研究的逐步深入,发现其在水产品和环境中药物残留问题不但威胁消费者的健康,并且制约水产行业的发展。因此国内外制定了甲砜霉素最大残留限量标准,而灵敏、高效和准确的残留检测分析方法对研究甲砜霉素显得至关重要。本文就近年来甲砜霉素在水生动物中的药理学、残留限量和残留检测技术研究进展3个方面进行综述,全面梳理和总结了甲砜霉素在水生动物体内的代谢残留规律、国内外残留限量标准和现今较为常用的检测技术,以期为水生动物疾病防治、合理用药方案制定和药物残留限量控制提供更全面的理论参考依据。 Thiamphenicol is the second generation of chloramphenicol broad-spectrum antibacterial drugs, both Gram-positive and Gram-negative bacteria have a good inhibitory effect on aquaculture of fish and turtles and other aquatic animal diseases Prevention has a very significant effect. With the gradual deepening research on thiamphenicol, it was found that the problem of drug residues in aquatic products and the environment not only threatened the health of consumers, but also restricted the development of the aquatic industry. Therefore, the maximum residue limit of thiamphenicol has been established both at home and abroad. However, the sensitive, efficient and accurate method for determination of thiamphenicol is very important for the study of thiamphenicol. In this paper, in recent years, thiamphenicol in aquatic animal pharmacology, residue limits and residue detection techniques are reviewed in three aspects, a comprehensive review and summary of thiamphenicol metabolism in aquatic animals residual law, residues at home and abroad Limited standards and today’s more commonly used detection techniques in order to provide a more comprehensive theoretical reference for the prevention and treatment of aquatic animal diseases, the formulation of rational drug use and the control of drug residue limits.