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本文对常规剂量利多卡因治疗无效的缺血性心脏病患者进行研究,旨在探索:①抑制室性心律失常所需的利多卡因每隔5分钟推注一次的最多次数,②左室衰竭对利多卡因血浆浓度时程的影响,③推注负荷剂量期间药物血浆浓度与效应的关系。方法:21例对常规负荷剂量利多卡因(225毫克利多卡因,注射16分钟)治疗无效的患者为研究对象,其中15例有急性心肌梗塞,6例患长期冠状动脉机能不全,21例中9例患有严重左室衰竭(肺
This article studies patients with ischemic heart disease who are ineffective at conventional doses of lidocaine to explore: 1) the maximum number of boluses of lidocaine required to inhibit ventricular arrhythmias every 5 minutes, 2) left ventricular failure The impact of lidocaine plasma concentration time course, ③ the relationship between the drug plasma concentration and effect during bolus load dose. METHODS: Twenty-one patients, who were ineffective in the conventional loading dose of lidocaine (225 mg lidocaine, 16 min injection), included 15 patients with acute myocardial infarction, 6 with long-term coronary insufficiency, 21 Nine patients had severe left ventricular failure (lungs