Background:Recrossing the compromised side branch (SB) with a balloon is sometimes technically challenging.The aim of this study was to evaluate whether in-stent anchoring (ISA) is safe and effective to facilitate SB balloon delivery for final kissing.Methods:One hundred and fifty-nine consecutive patients were included (166 bifurcation lesions) in this prospective,single-center registry.ISA was used as a bailout method after unsuccessful SB crossing using conventional techniques,including low-profile balloons.Technique success was defined as SB balloon delivery and final kissing.Results:Kissing-balloon delivery was successfully performed with conventional strategies in 149 of 166 lesions (89.8％).In the remaining 17 lesions (10.2％),recrossing of the main vessel stent strut was not successful;therefore,ISA was attempted.The balloon successfully crossed the stent struts,and final kissing was achieved in 15 of 17 lesions (88.2％).Total final kissing was achieved in 164 of 166 lesions (98.8％),with success rates of 100％ in the single-stent group and 97.6％ in the two-stent group.Two cases without balloon delivery had complex bifurcation lesions with severe calcification.There was no vessel dissection in the anchoring zone.Conclusions:ISA is safe and effective for recrossing stent struts when conventional low-profile balloons have failed.However,large-scale trials are warranted for further evaluation.