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目的探讨鼻咽癌组织局部CD8+和PD-1+淋巴细胞在鼻咽癌发生发展中的作用。方法采用免疫组化方法检测64例鼻咽癌肿瘤组织和20例慢性鼻咽炎组织的CD8+和PD-1+淋巴细胞的分布情况。结果鼻咽癌肿瘤组织中CD8+淋巴细胞百分比为(10.68±6.81)%,与慢性鼻咽炎组织的(28.5±9.33)%比较,差异有统计学意义(P<0.05);鼻咽癌组织中PD-1+淋巴细胞为(10.4±5.95)%,与鼻咽炎组织的(6.8±3.21)%比较,差异有统计学意义(P<0.05)。鼻咽癌组织中PD-1+/CD8+淋巴细胞比率为(1.24±0.91),与鼻咽炎组织(0.28±0.2)比较,差异有统计学意义(P<0.001),但PD-1+/CD8+淋巴细胞比率升高与鼻咽癌临床分期无关。结论鼻咽癌组织中CD8+淋巴细胞减少,PD-1+淋巴细胞增加,提示PD-1可能参与鼻咽癌免疫逃逸,与鼻咽癌的发生有关。
Objective To investigate the role of local CD8 + and PD-1 + lymphocytes in the development of nasopharyngeal carcinoma in nasopharyngeal carcinoma. Methods The distribution of CD8 + and PD-1 + lymphocytes in 64 cases of nasopharyngeal carcinoma and 20 cases of chronic nasopharyngitis were detected by immunohistochemistry. Results The percentage of CD8 + lymphocytes in nasopharyngeal carcinoma was (10.68 ± 6.81)%, which was significantly higher than that in chronic nasopharyngitis (28.5 ± 9.33)% (P <0.05) (10.4 ± 5.95)% for lymphocytes of (-1) + and (6.8 ± 3.21)% of nasopharyngitis tissues (P <0.05). The ratio of PD-1 + / CD8 + lymphocytes in nasopharyngeal carcinoma was (1.24 ± 0.91), which was significantly different from that in nasopharyngitis (0.28 ± 0.2) (P <0.001) Lymphocyte ratio increased with the clinical stage of nasopharyngeal carcinoma has nothing to do. Conclusions The decrease of CD8 + lymphocytes and the increase of PD-1 + lymphocytes in nasopharyngeal carcinoma suggest that PD-1 may be involved in the immune escape of nasopharyngeal carcinoma, which is related to the occurrence of nasopharyngeal carcinoma.