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Background:Evidence shows an association between grip strength and health;however, grip strength cut-offs for the detection of metabolic syn-drome (MetS) in Latin American populations are scarce. The purpose of this study was to determine cut-offs of normalized grip strength (NGS) for the detection of MetS in a large nonrepresentative sample of a collegiate student population from Colombia.Methods:A total of 1795 volunteers (61.4％female;age=20.68 ± 3.10 years, mean ± SD), ranging between 18 and 30 years of age partici-pated in the study. Strength was estimated using a handheld dynamometer and normalized to body mass (handgrip strength (kg)/body mass (kg)). Anthropometrics, serum lipids indices, blood pressure, and fasting plasma glucose were measured. Body composition was measured by bioelectrical impedance analysis. MetS was defined as including≥3 of the 5 metabolic abnormalities according to the Intational Diabetes Federation definition. A metabolic risk score was computed from the following components:waist circumference, triglycerides, high-density lipoprotein cholesterol, glucose, and systolic and diastolic blood pressure.Results:Receiver operating curve analysis showed significant discriminatory accuracy of NGS in identifying the thresholds and risk categories. Lower strength was associated with increased prevalence of MetS. In males, weak, intermediate, and strong NGS values at these points were<0.466, 0.466-0.615,>0.615, respectively. In females, these cut-off points were<0.332, 0.332-0.437,>0.437, respectively.Conclusion:Our sex-specific cut-offs of NGS could be incorporated into a clinical setting for identifying college students at cardiometabolic dis-ease risk.