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目的建立质量分数高于99.0%灯盏花乙素的吸附树脂法分离工艺。方法根据灯盏花乙素、灯盏花甲素结构特征,综合调控树脂的疏水性和氢键作用力,达到树脂的高吸附选择性。结果MA比例为45%的酰胺基树脂ac-3吸附选择性最佳。以灯盏花提取物为原料,可分离得到质量分数高达99.4%的灯盏花乙素。结论兼具疏水性和氢键作用力相互协同作用的酰胺基树脂,可高选择性的吸附灯盏花甲素,达到分离纯化灯盏花乙素的目的。该分离工艺操作简单,成本低廉,适于工业化生产。
OBJECTIVE To establish an adsorption resin method for the separation of scutellarin with a mass fraction higher than 99.0%. Methods According to the structural features of scutellarin and scutellarin, the hydrophobic and hydrogen bonding forces of the scaffolds were comprehensively controlled to achieve the high selectivity of the resin. As a result, the acylamino-group resin ac-3 with 45% MA ratio had the best adsorption selectivity. Erigeron extract as raw material, can be separated by mass fraction of up to 99.4% of the scutellarin. Conclusions The amide-based resin, which has the synergistic effect of hydrophobicity and hydrogen bonding force, can adsorb Eriochrome with high selectivity and achieve the purpose of separating and purifying Erigeron. The separation process is simple, low cost, suitable for industrial production.