英国的帝国化学工业公司(ICI)制药部最近透露,在英国开始使用一种新的每日服一次的血管紧张素转化酶(ACE)抑制剂-Zestril(lisinopri),它与一种利尿药配合用于高血压和充血性心力衰竭的辅助治疗。 Zestril是一种口服有效而不含巯基的非前体药物。临床研究表明用该药治疗轻度或中度高血压病比双氢氯噻嗪和β-阻滞剂更有效。据ICI称该药对重度高血压病患者的疗效与硝苯吡啶一样,且很少引起副作用。和巯甲丙脯酸比较Zestril能大大延长持续时间,对心力衰竭病人的症状改善也较明显。 Recently, the British Ministry of Pharmaceutical Industry’s (ICI) Pharmaceutical Division recently disclosed that a new daily ACE inhibitor, lisinopri, has been used in the UK in combination with a diuretic For the treatment of hypertension and congestive heart failure. Zestril is an orally available, non-prodrug-free, non-prodrug. Clinical studies have shown that the drug used to treat mild or moderate hypertension than hydrochlorothiazide and β-blockers more effective. According to ICI, the drug has the same efficacy as nifedipine in patients with severe hypertension and rarely causes side effects. Compared with captopril Zestril can greatly extend the duration of the symptoms of heart failure patients to improve more obvious.