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目的观察三维适形放射治疗联合5-氟尿嘧啶(5-FU)加顺铂(DDP)同步化疗治疗食管癌的疗效及耐受性。方法 70例食管癌患者采用三维适形放疗1.8～2gY/f,1f/d,至60～66gY,同步化疗FP方案:顺铂25mg/m2,d1-d3,5-FU600mg/m2,d1-d3,28天为1周期,共4个周期。结果食管癌同步放化疗的有效率77%,1、3、5年生存率分别为64%、42%,38%。主要毒副反应表现为骨髓抑制和消化道反应。结论三维适形放射治疗联合化疗治疗食管癌近期疗效好,且毒副反应可以耐受。
Objective To observe the efficacy and tolerability of three-dimensional conformal radiotherapy combined with 5-fluorouracil (5-FU) and cisplatin (DDP) in the treatment of esophageal cancer. Methods Seventy patients with esophageal cancer underwent three-dimensional conformal radiotherapy of 1.8 ~ 2gY / f, 1f / d to 60 ~ 66gY. The concurrent chemotherapy FP regimen: cisplatin 25mg / m2, d1-d3,5-FU600mg / m2, d1-d3 , 28 days for a cycle, a total of 4 cycles. Results The effective rate of concurrent chemoradiotherapy for esophageal cancer was 77%, and the 1, 3, 5-year survival rates were 64%, 42% and 38% respectively. The main toxicities manifested as myelosuppression and gastrointestinal reactions. Conclusion Three-dimensional conformal radiotherapy combined with chemotherapy for the treatment of esophageal cancer has a good short-term effect, and toxicity can be tolerated.