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目的观察颅脑损伤患者血清及CSF中tau及Aβ42水平的变化及其意义。方法对本院2014年7月~2016年4月收入的60例颅脑损伤患者进行血清及CSF中tau蛋白及Aβ42的表达水平检测,分析其与患者损伤程度及预后的关系。结果和对照组相比,试验A组和B组颅脑损伤患者血清及CSF中tau蛋白水平和Aβ42水平显著升高。不同时间GCS A组患者血清及CSF中tau蛋白水平和Aβ42水平显著高于GCS B组(P<0.05)。与GCS A组相比,GCS B组GOS评分为1~3分的患者比例显著降低,GOS评分为4~5分的患者比例显著增加(P<0.05)。结论 tau蛋白水平、Aβ42表达水平与颅脑损伤密切相关,可作为颅脑损伤患者预后的重要评价指标,而且Aβ42在重型创伤性颅脑损伤患者伤后认知功能障碍的病理生理机制中可能发挥着重要作用。
Objective To observe the changes of tau and Aβ42 levels in serum and CSF in patients with craniocerebral injury and its significance. Methods The serum and CSF levels of tau protein and Aβ42 were detected in 60 patients with craniocerebral injury from July 2014 to April 2016 in our hospital. The relationship between them was analyzed with the degree of injury and the prognosis. Results Compared with the control group, the levels of tau protein and Aβ42 in serum and CSF of patients in experimental group A and group B were significantly increased. The levels of tau protein and Aβ42 in serum and CSF of patients with GCS A at different times were significantly higher than those of GCS B (P <0.05). Compared with GCS group A, the proportion of patients with GOS score of 1 to 3 in GCS B group was significantly decreased, and the proportion of patients with GOS score of 4 to 5 was significantly increased (P <0.05). Conclusion The level of tau protein and Aβ42 expression are closely related to the brain injury, which may be used as an important evaluation index for the prognosis of patients with craniocerebral injury. Moreover, Aβ42 may play a role in the pathophysiological mechanism of post-traumatic cognitive impairment in patients with severe traumatic brain injury An important role.