目的　研究盐酸二甲双胍胶囊在正常人体内的药物动力学和相对生物利用度。方法　１０ 例健康男性志愿者，随机分为两组，分别交叉口服盐酸二甲双胍胶囊和片剂采用通过反相 Ｈ Ｐ Ｌ Ｃ 法测定盐酸二甲双胍在体内的药物浓度。结果　口服１ ０００ ｍｇ 盐酸二甲双胍胶囊片剂的达峰时间（ Ｔｍａｘ） 分别为１８３ ｈ ±０５６ ｈ 和１８３ ｈ ±０５０ ｈ ；峰浓度（ Ｃｍａｘ） 分别为２２５ ｍｇ· Ｌ－ １ ±０４９ ｍｇ· Ｌ－ １ 和２２４ ｍｇ· Ｌ－ １±０５０ ｍｇ· Ｌ－ １ ；消除半衰期（ Ｔ１／２β） 分别为２４０ ｈ ±０２３ ｈ和２４０ ｈ ±０２８ ｈ ；药时曲线下面积（ Ａ Ｕ Ｃ） 分别为１３４１ ｍｇ·ｈ － １· Ｌ－ １ ±３５５ ｍｇ·ｈ － １· Ｌ－ １ 和１２９９ ｍｇ·ｈ － １· Ｌ－ １ ±３３９ｍｇ·ｈ － １· Ｌ－ １ ，经ｔ 检验，两种剂型的药代动力学参数无显著性差异；口服盐酸二甲双胍胶囊对其片剂的相对生物利用度为１０３２４ ％ 。结论　两种制剂具有生物等效性。 Objective To study the pharmacokinetics and relative bioavailability of metformin hydrochloride capsules in normal human. Methods Ten healthy male volunteers were randomly divided into two groups. Metformin hydrochloride capsules and tablets were administered orally. The drug concentration of metformin hydrochloride in the body was determined by reversed-phase H PLC method. Results The peak time (Tmax) of 1 000 mg oral metformin hydrochloride capsules was 1.83 h ± 056 h and 183 h ± 050 h, respectively. The peak concentrations (Cmax) were 225 mg · L ± 1 ± 049 mg · L -1 and 224 mg · L -1 ± 050 mg · L -1; elimination half-life (T1 / 2β) were 240 h ± 023 h And 240 h ± 028 h respectively. The area under the curve (A U C) was 1341 mg · h -1 · 1 ± 355 mg · h -1 · L -1 and 12 respectively  99 mg · h - 1 · L- 1 ± 339 mg · h - 1 · L - 1. There was no significant difference in the pharmacokinetic parameters between the two formulations by t test. The oral administration of metformin hydrochloride capsule had no significant difference The relative bioavailability of 10324%. Conclusions Both formulations are bioequivalent.