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血管瘤是小儿较为常见的皮肤良性肿瘤之一,由胚胎期血管网增生所致。血管瘤是一种先天性发育异常,属于错构瘤,而非真性肿瘤。病变部位皮肤细胞增殖是血管瘤发生的主要特点之一,并具有自行消退的特性[1-2]。血管瘤的自行消退机制仍处于不断探索中,但有研究显示,细胞凋亡在血管瘤自行消退过程中发挥重要作用。PI3K-Akt是目前证实在介导细胞凋亡过程中发挥重要作用的信号通路。
Hemangioma is one of the more common benign tumors of the skin in children, caused by the hyperplasia of the vascular network during embryogenesis. Hemangiomas are congenital dysplasias that belong to hamartomas, but not to true tumors. Lesions of skin cell proliferation is one of the main features of hemangiomas, and has its own characteristics of regression [1-2]. The mechanism of autonomic regression of hemangiomas is still under continuous exploration, but studies have shown that apoptosis plays an important role in the process of hemangioma self-resolution. PI3K-Akt is a signaling pathway that has been shown to play an important role in mediating apoptosis.