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目的:观察冠心病患者阿司匹林抵抗的发生率是否与正常人群有差异。方法:心内科住院的冠心病病人50例和正常对照组30例每天服用阿司匹林100mg,7天后用二磷酸腺苷(ADP)、花生四烯酸(AA)作为血小板聚集诱导剂检测定血小板聚集率。结果:在50例冠心病患者中,阿司匹林完全抵抗发生率为12%(6/50);阿司匹林半抵抗发生率为26(13/50),阿司匹林敏感率为62%(31/50)。在30例正常对照组中,阿司匹林完全抵抗发生率为13.3%(4/30);阿司匹林半抵抗发生率为26.6%(8/30),阿司匹林敏感率为60.1%(18/30)。结论:冠心病患者阿司匹林抵抗的发生率是与正常人群没有差异。
Objective: To observe whether the incidence of aspirin resistance in patients with coronary heart disease is different from the normal population. Methods: 50 hospitalized patients with coronary heart disease and 30 normal subjects received aspirin 100 mg daily for 7 days. ADP and AA were used as platelet aggregation inducer to determine platelet aggregation rate . RESULTS: In 50 patients with coronary heart disease, the complete resistance rate of aspirin was 12% (6/50), that of aspirin was 26 (13/50), and that of aspirin was 62% (31/50). In the 30 normal control group, the complete resistance rate of aspirin was 13.3% (4/30), the incidence of aspirin half-resistance was 26.6% (8/30), and aspirin sensitivity was 60.1% (18/30). Conclusion: The incidence of aspirin resistance in patients with coronary heart disease is no different from the normal population.