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苦参碱类生物碱具有多方面的药理作用和生物活性,近年来已广泛应用于临床各科。在抗肿瘤方面,因可以有效抑制肿瘤细胞的增殖和诱导肿瘤细胞凋亡而受到了极大的关注,特别是苦参碱和氧化苦参碱能抑制肿瘤细胞DNA的合成、抑制相关酶活性、影响肿瘤细胞的正常周期来抑制肿瘤细胞增殖;通过控制相关因子的表达来抑制肿瘤的转移;通过影响与肿瘤相关基因的表达、影响端粒酶的活性等途径,来诱发细胞发生凋亡,诱导肿瘤细胞向正常细胞分化等。本文就其体内吸收代谢及抗癌作用进行综述。
Matrine alkaloids have many aspects of pharmacological effects and biological activity, in recent years has been widely used in clinical subjects. In the anti-tumor, because it can effectively inhibit tumor cell proliferation and induce apoptosis of tumor cells have received great attention, especially matrine and oxymatrine can inhibit DNA synthesis in tumor cells, inhibit the activity of related enzymes, Affect the normal cycle of tumor cells to inhibit the proliferation of tumor cells; inhibit the metastasis of tumor by controlling the expression of related factors; induce the apoptosis of cells by affecting the expression of tumor-related genes and affecting the activity of telomerase, etc. Tumor cells differentiate into normal cells. This article reviews the body’s absorption and metabolism and anti-cancer effects.