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目的探讨慢性乙型肝炎患者血清铁蛋白(SF)、血清铁(SI)、转铁蛋白(TF)的变化与其他血清学指标的关系和患者病情程度的相关性。方法分别检测慢性乙型肝炎轻度患者231例、中度患者144例、重度患者84例和健康体检者103例的血清铁蛋白、血清铁、转铁蛋白,并同时测定血清丙氨酸氨基转移酶(ALT)、血清天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)、血清白蛋白(ALB)、血清胆碱酯酶(CHE)的浓度。结果不同研究组之间SF、SI、TF检测结果差异有统计学意义(P<0.05),随着病情的加重,SF、SI呈升高趋势,TF呈降低趋势。SF浓度与慢性乙型肝炎轻度组、中度组和重度组患者血清ALT、AST、TBIL浓度呈正相关(P<0.05),与ALB、CHE浓度呈负相关(P<0.05)。结论血清铁代谢相关指标与慢性乙型肝炎患者病情轻重程度相关,检测铁代谢相关指标有助于监测慢性乙型肝炎患者病情变化,为临床诊疗提供帮助。
Objective To investigate the relationship between the changes of serum ferritin (SF), serum iron (SI) and transferrin (TF) in patients with chronic hepatitis B and other serological markers and the severity of the disease. Methods Serum ferritin, serum iron and transferrin were detected in 231 patients with mild hepatitis B, 144 with moderate disease, 84 with severe disease and 103 with healthy subjects respectively. Serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), serum total bilirubin (TBIL), serum albumin (ALB) and serum cholinesterase (CHE). Results The results of SF, SI and TF in different study groups were statistically significant (P <0.05). With the severity of the disease, SF, SI increased and TF decreased. SF concentrations were positively correlated with serum ALT, AST and TBIL concentrations in mild, moderate and severe chronic hepatitis B patients (P <0.05), but negatively correlated with ALB and CHE concentrations (P <0.05). Conclusion Serum iron metabolism related to the severity of chronic hepatitis B patients, the detection of iron metabolism related indicators help to monitor changes in patients with chronic hepatitis B, to provide help for clinical diagnosis and treatment.