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为探讨小儿危重病血清组织释放酶改变及其临床意义，将１１８例患儿按危重病例评分值分为－１００分，－８０分，０－７０分３组．其中死亡２０例，存活９８例．应用欧林巴斯ＡＵ－１０００型全自动生化分析仪分别测定患儿血清天冬氨酸转氨酶（ＡＳＴ）、丙氨酸氨基转移酶（ＡＬＴ）、乳酸脱氢酶（ＬＤＨ）及同功酶（ＬＤ－Ｉ）、肌酸磷酸激酶（ＣＰＫ）及同功酶（ＣＰＫ－ＭＢ）、碱性磷酸酶（ＡＫＰ）、酸性磷酸酶（ＡＣＰ）、γ－谷氨酸转肽酶（γ-ＧＴ）、α-羟丁酸脱氢酶（αＨＢＤ），结果表明：－１００分组血清１０种酶值大多在正常范围，与正常健康儿童对照无显著差异（Ｐ＞０．０５）；－８０分和０－７０分２组酶值明显高于正常健康儿童（Ｐ＜０，０１），评分值越低，病情越重，各种酶越高；死亡组酶值高于存活组（Ｐ＜０．０１）．测定血清组织释放酶，对危重儿童病情判断及预后有参考价值．
In order to explore the changes of Serum Tissue Releasing Enzyme in children with critical illness, 118 children were divided into three groups according to their critical cases score of -100, -80 and 0-70. Among them, 20 died and 98 survived. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH) and isozyme LD-I, CPK and CPK-MB, AKP, ACP, γ-GT, , Α-hydroxybutyrate dehydrogenase (αHBD). The results showed that most of the 10 enzymes in -100 group were in the normal range and had no significant difference with normal healthy children (P> 0.05) -70 scores were significantly higher than those in normal healthy children (P <0,01). The lower the scores, the heavier the disease and the higher the various enzymes; the higher the death rate was (P <0.01) ). Determination of serum tissue release of enzymes, critically ill children’s judgment and prognosis of reference value.