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细胞移植可以修复和治疗人体损伤及功能性障碍的组织器官,但体内分离获得可以用于治疗相应疾病的功能性细胞在来源和数量上受到极大限制。因此,如何在体外获得合适的功能性细胞成为重要的科学问题。目前,体外功能性细胞的获得取得了突破性进展。现主要对体外通过胚胎干细胞/诱导多能干细胞分化或体细胞间转分化获取的功能性细胞的研究进展及应用前景进行综述,以期进一步推动我国在功能性细胞获得的基础研究及临床转化。
Cell transplantation can repair and treat the tissues and organs of human body injury and dysfunction, but the functional cells isolated in vivo and can be used to treat the corresponding diseases are greatly limited in source and quantity. Therefore, how to obtain appropriate functional cells in vitro has become an important scientific issue. At present, the progress of obtaining functional cells in vitro has made a breakthrough. The main research progress and application prospect of functional cells obtained from embryonic stem cells / induced pluripotent stem cells differentiation or somatic transdifferentiation in vitro are reviewed in order to further promote the basic research and clinical transformation of functional cells in our country.