目的 :了解灵黄口服液的安全性。方法 :小鼠急性经口毒性试验 ,Ames试验 ,小鼠骨髓嗜多染红细胞微核试验 ,雄性小鼠精子畸形分析 ,小鼠睾丸生殖细胞染色体畸变分析 ,大鼠传统致畸试验等 ,大鼠 90天喂养试验。结果 :该口服液急性经口毒性为无毒 ,在四项遗传毒性试验中均为阴性结果 ,在传统致畸试验中未见大鼠发育毒性和胚胎毒性 ,在 90天喂养试验中也无异常发现。结论 :灵黄口服液安全无毒 Objective: To understand the safety of Ling Huang oral liquid. Methods: Acute oral toxicity test in mice, Ames test, micronucleus test of mouse bone marrow polychromatic erythrocytes, sperm deformity analysis in male mice, chromosomal aberration analysis in mouse testes germ cells, traditional teratogenicity test in rats, etc. 90 days feeding test. Results: Acute oral toxicity of the oral solution was non-toxic, negative results in the four genotoxicity tests, no developmental toxicity and embryotoxicity in rats in conventional teratogenicity test, no abnormalities in the 90-day feeding test Find. Conclusion: Linghuang oral liquid is safe and non-toxic