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作者回顾分析1957～1986年间的MD Anderson癌症中心收治的41例腭部腺样囊性癌病例,其中男性22例,女性19例,年龄20～82岁(平均54岁)。按肿瘤浸润范围和生长方式将患者分为三组,第一组(17例):肿瘤局限于腭部,第二组(13例):临床或X线检查证实肿瘤侵及邻近组织,如鼻腔、副鼻窦或翼肌;第三组(11例):显微镜下检查,肿瘤浸润范围远远超出切缘(切缘阳性)。病理检查示,肿瘤侵及鼻粘膜、鼻甲和翼肌。38例肿瘤起于硬腭粘膜,2例起于软腭,1例位于软硬腭交界处。初诊时所有患者均无局部或远处转移证据,所有患者均以手术治疗,其中22例接受术后放疗。侵犯周围神经者,放疗剂量为50～60Gy;侵犯上颌骨者,放疗剂量为54～60Gy;切缘阳性者,放疗剂量为55～60Gy。分析患者年龄,肿瘤侵犯范围,手术治疗,放射治疗,病理所见与生存率之间的关系。
The authors retrospectively analyzed 41 cases of adenoid cystic carcinoma of the axilla treated at the MD Anderson Cancer Center between 1957 and 1986, including 22 males and 19 females, aged 20-82 years (average 54 years). Patients were divided into three groups according to the extent of tumor invasion and growth patterns. The first group (17 cases): the tumor was confined to the ankle and the second group (13 cases): Clinical or X-ray examination confirmed that the tumor invaded adjacent tissues, such as nasal cavity , Paranasal sinuses or pterygoids; Group III (11 cases): Microscopic examination, tumor invasion far beyond the margin (positive margin). Pathological examination showed that the tumor invaded the nasal mucosa, turbinates and pterygoids. Thirty-eight cases of tumor originated from hard palate mucosa, 2 cases from soft palate and 1 case at the junction of soft palate and hard palate. At the time of the initial diagnosis, there was no evidence of local or distant metastasis in all patients. All patients were treated with surgery, and 22 patients received postoperative radiotherapy. Peripheral nerve invasion, radiotherapy dose of 50 ~ 60Gy; violations of the maxilla, radiation dose of 54 ~ 60Gy; positive margin, radiation dose of 55 ~ 60Gy. The relationship between patient age, tumor invasion range, surgical treatment, radiation therapy, pathological findings and survival rate was analyzed.