论文部分内容阅读
大量研究表明激活中枢神经系统N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体在神经病理性疼痛的产生和维持中起重要作用,NMDA受体拮抗剂可以有效地缓解疼痛。因此对NMDA受体亚基特异拮抗剂特别是对NR2B拮抗剂的研究有可能成为未来的研究热点。本文综述了NMDA受体的分布及其特异性亚基在疼痛中的作用,从而为临床治疗神经病理性疼痛提供新的靶点。
Numerous studies have shown that activation of N-methyl-D-aspartate (NMDA) receptors in the central nervous system plays an important role in the production and maintenance of neuropathic pain. NMDA receptor antagonists can Effectively relieve pain. Therefore, NMDA receptor subunit specific antagonist, especially for NR2B antagonist research may become the future research focus. This review summarizes the distribution of NMDA receptors and the role of their specific subunits in pain, thus providing a new target for the clinical treatment of neuropathic pain.