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目的:对荆门地区2014年药品不良反应(ADR)报告情况进行统计分析,并与前3年的数据进行比较,为ADR监测工作提供参考。方法:收集荆门地区2014年各单位上报国家药品不良反应监测中心的2 303份ADR报告,通过患者基本情况、报告单位、ADR类型、药品种类、结果评价等方面进行回顾性分析。同时回溯2011~2013年上报的ADR报告数据进行对比分析。结果:2 303例ADR报告中,以医疗机构的报告为主,占99.8%;静脉滴注引起的ADR占81.0%;抗感染药引起的ADR占43.7%,以头孢菌素所致ADR最多;引起免疫系统的ADR最多,占38.1%;严重ADR病例较2013年增加1.4%;市ADR中心评价结果为“很可能”的ADR最多,占72.7%;百万人口ADR的发生比例为767例。结论:重视ADR监测工作,重点关注新的严重ADR,提高医务人员对ADR的认识,提高合理用药水平,鼓励主动上报ADR并保证上报内容的准确性。
OBJECTIVE: To conduct a statistical analysis on the adverse drug reaction (ADR) reports in 2014 in Jingmen area and compare with the data of the previous three years to provide reference for ADR monitoring. Methods: A total of 2 303 copies of ADR reports from all agencies reporting to ADRM in Jingmen area in 2014 were collected and retrospectively analyzed according to patient’s basic information, reporting unit, ADR type, drug type, and outcome evaluation. At the same time back to 2011-2013 reported ADR report data for comparative analysis. Results: The 2 303 ADR reports were mainly reported by medical institutions, accounting for 99.8%. The ADR caused by intravenous infusion accounted for 81.0%. The ADR caused by anti-infective drugs accounted for 43.7%. The most ADR was caused by cephalosporin. The ADRs causing the most immune system accounted for 38.1% of all cases; severe ADR cases were 1.4% more than in 2013; ADR centers rated as “most probable” with the highest ADR, accounting for 72.7%; ADRs occurring in 1 million people were 767 example. CONCLUSIONS: Paying great attention to ADR monitoring, focusing on new serious ADRs, improving medical staff’s understanding of ADRs, raising the level of rational drug use, and encouraging active reporting to ADRs and ensuring the accuracy of the reported contents.