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几年来,国外对多发性硬化症(MS)和格林-巴里氏综合征(GBS)的免疫学发病机理进行了广泛研究,发现MS 和GBS 可能有免疫调节异常,包括细胞免疫抑制功能减弱,体液免疫功能亢进,血清中免疫球蛋白及循环免疫复合物(CIC)水平增高等。因此,检测CIC 等免疫指标可能对探讨MS 免疫学发病机理有一定意义。为此,我们应用~(125)ⅠC_1q 结合实验,测定了MS 和GBS 病人血清中CIC 水平及激素对CIC 水平的影响。材料和方法一、病例选择1、MS 组:14例MS 病人,男5例,女9例,年龄16～44岁,平均24.8岁,系我校附属第一、第二医院神经科按McDonald 诊断标准确诊的住院病人。(1)糖皮质激素用药前组:14例MS 病人,采样前至少6周末接受皮质类固醇激素治疗。
In recent years, extensive studies have been conducted on the immunological pathogenesis of multiple sclerosis (MS) and Guillain-Barré Syndrome (GBS) in foreign countries. It is found that MS and GBS may have immunomodulatory abnormalities including weakened cellular immunosuppression, Immune hyperactivity, serum immunoglobulin and circulating immune complex (CIC) levels increased. Therefore, the detection of immune indicators such as CIC may be of some significance to explore the pathogenesis of MS immunology. To this end, we used ~ (125) ⅠC_1q binding assay to determine the serum levels of CIC in MS and GBS patients and the effect of hormones on CIC levels. Materials and Methods 1. Case Selection 1. MS group: 14 MS patients, 5 males and 9 females, aged from 16 to 44 years (average 24.8 years old), Department of Neurology, the First and Second Affiliated Hospital of our school according to McDonald’s diagnosis Standard diagnosed inpatient. (1) pre-glucocorticoid group: 14 patients with MS, sampling at least 6 weeks before receiving corticosteroid therapy.