两种不同剂量A型肉毒毒素治疗偏头痛的疗效观察

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目的观察50U、100U两种不同剂量A型肉毒毒素(BTX-A)治疗偏头痛的疗效。方法头痛患者60例,随机分为2组,均选颅周肌肉相同的注射位点。I组注射BTX-A50U;Ⅱ组注射BTX-A100U。分别于0、30、90d观察头痛程度、发作频率、生活质量及不良反应。结果①I组治疗前与治疗后30、90d时,头痛视觉模拟评分(VAs)分别7.2、4.6、4.2;Ⅱ组分别为7.1、3.3、3.1。两组治疗前后比较差异有统计学意义,组间比较差异有统计学意义。②I组治疗前与治疗后30、90d时,头痛发作频率分别6.4次/月、4.6次/月、4.2次/月;Ⅱ组分别为6.3次/月、4.3次/月、4.2次/月。两组治疗前后有统计学意义,组间无统计学意义。③两组均能改善生活质量,组间无统计学意义。④各组不良反应均较轻。结论 A型肉毒毒素(BTX-A)注射可有效减轻偏头痛患者的头痛程度、减少发作频率、提高生活质量;100UBTX-A对头痛程度的减轻优于50UBTX-A,头痛发作频率、生活质量的改善与剂量无关。两组均不良反应轻微。 Objective To observe the curative effect of two different doses of botulinum toxin type A (BTX-A) 50U and 100U on migraine. Methods Sixty patients with headache were randomly divided into two groups, all of which were injected with the same injection sites of the cranial muscles. Group I was injected BTX-A50U; Group II was injected BTX-A100U. Headache, frequency of seizure, quality of life and adverse reactions were observed at 0, 30 and 90 days respectively. Results ①The headache visual analogue scale (VAs) before treatment and at 30 and 90 days after treatment in group I were 7.2, 4.6 and 4.2, respectively, and in group II were 7.1, 3.3 and 3.1 respectively. The difference between the two groups before and after treatment was statistically significant, the difference between the two groups was statistically significant. ② The frequency of headache attack in group I before treatment and at 30 and 90 days after treatment were 6.4 / month, 4.6 / month and 4.2 / month respectively; in group Ⅱ 6.3 and 4.3 / month and 4.2 / month respectively. The two groups had statistical significance before and after treatment, with no significant difference between the two groups. ③ Both groups can improve the quality of life, no statistically significant between groups. ④ adverse reactions in each group are lighter. Conclusion BTX-A injection can effectively alleviate the headache, reduce the frequency of seizures and improve the quality of life in migraine patients. The 100UBTX-A can relieve headache more effectively than 50UBTX-A, the frequency of headache attacks and the quality of life The improvement is dose-independent. Adverse reactions were mild in both groups.
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