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目的:观察高原(2300m~3700m)扁桃体反复感染伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血中C-反应蛋白(CRP)、肿瘤细胞坏死因子-a(TNF-a)水平影响。方法:选择通过多导睡眠仪(PSG)确诊的30例OSAHS患者和29例正常对照组。用放射免疫法测定两组血清TNF-a水平,用散射比浊法测定两组血清CRP水平,进行对照分析。结果:OSAHS患者呼吸暂停-低通气指数(AHI)与CRP、TNF-a水平呈正相关(r=0.37,P<0.01),与夜间最低SaO2呈负相关(r=-0.56,P<0.001)。OSAHS患者CRP、TNF-a水平较对照组显著性增高(P<0.001)。结论:OSAHS患者CRP、TNF-a血清水平增高与炎症、低氧血症的发生相关。
Objective: To observe the effects of C-reactive protein (CRP) and tumor necrosis factor-a (TNF-a) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) on repeated tonsil infection from 2300 m to 3700 m. METHODS: Thirty OSAHS patients and 29 normal controls diagnosed by polysomnography (PSG) were selected. Serum levels of TNF-a were measured by radioimmunoassay. Serum CRP level was measured by nephelometry. Results: There was a positive correlation between AHI and CRP and TNF-a levels in OSAHS patients (r = 0.37, P <0.01), but negatively correlated with nighttime lowest SaO2 (r = -0.56, P <0.001). OSAHS patients CRP, TNF-a levels were significantly higher than the control group (P <0.001). Conclusion: The serum levels of CRP and TNF-α in OSAHS patients are correlated with the occurrence of inflammation and hypoxemia.