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卵巢内胚窦瘤是罕见而主要发生于儿童和青年的高度恶性生殖细胞肿瘤。近年来才认识到是一个独立疾病单元,在命名上有多种争论,最近才合理的分期研究了其生物学特性及做出有效的治疗方法。 1939年Schiller描述提出来源于中肾的一组卵巢肿瘤。1946年Teillum首次反驳中肾起源学说,认为来源于胚外的生殖细胞,看到此瘤与鼠胎盘卵黄囊的Duval内胚窦相似,称为内胚窦瘤。通过免疫组织学鉴定,患者血清中甲胎蛋白水平升高,更是与卵黄囊密切有关的证据。1976年Kurman和Nor-
Ovarian endodermal sinus tumors are rare and predominantly malignant germ cell tumors in children and young adults. In recent years, it has been recognized as an independent disease unit. There are many controversies on naming. Only recently has it been reasonable to study the biological characteristics of staging and to make effective treatment. 1939 Schiller describes a group of ovarian tumors originating from the kidney. In 1946 Teillum first refuted the theory of mesocolon origin, that derived from the extraembryonic germ cells, see this tumor and placental yolk sac Duval endoderm similar, known as endodermal sinus tumor. Immunohistological identification of patients with serum alpha-fetoprotein levels, but also with yolk sac closely related evidence. 1976 Kurman and Nor-